In Diablo II: Resurrected, obtaining rare items can be quite challenging, while common items are easy to come by. However, you can make good use of these common D2R Runes by imbuing them and turning them into magical equipment.
The process of imbuing items in Diablo II is available early in the game. During Act 1, completing one of the six quests will reward you with this ability as a bonus. Specifically, we're referring to the Horadric Malus, which you can obtain from Charsi after completing the "Forgotten Tower" quest or reaching at least level 8 and finding Deckard Cain in the camp.
Once you retrieve the Horadric Malus from Smith, bring it back to Charsi to complete the quest. As a reward, she will grant you a free imbue potion.
Imbuing allows you to transform a normal item into a magical one (as long as it isn't already magical, socketed, rare, unique, set, or part of a jewel). Additionally, the attributes added to the item depend on your current level - the higher your level, the more attributes it will gain after imbuing.
To imbue an item, simply talk to Charsi at any time and select the dialogue option to imbue an item. Choose the item you want to imbue, and she will perform the process for you. While the process is quite straightforward, the main question is when to perform this action, as it's a rare opportunity.
For the best results, it's recommended to wait until you are at a higher level, or if you really want to seize the chance earlier, consider using this mechanism with unique items. Keep in mind that there's a risk/reward factor in the game since you never know what attributes you'll get, and all the previous attributes of the item will be replaced.
When it comes to what to imbue in Diablo II, exceptional and elite items are good choices. Additionally, imbuing crowns (a specific type of helmet) can be a great option in Diablo II as they are excellent for providing attributes.
Using the imbue option with Charsi can yield some decent results, but luck will surely play a part. So, be patient, and if you don't have enough time to invest, you can also consider Buy D2R Runes directly from RPGStash. They offer all kinds of D2R items for sale, especially D2R Runes, which can save you a lot of time as a player.